Total synthesis and biological evaluation of (-)-exiguolide analogues: Importance of the macrocyclic backbone

Haruhiko Fuwa, Kana Mizunuma, Makoto Sasaki, Takaya Suzuki, Hiroshi Kubo

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

(-)-Exiguolide (1), isolated from the marine sponge Geodia exigua, has been shown to inhibit the growth of the A549 human lung adenocarcinoma and NCI-H460 human lung large cell carcinoma cells in vitro. In this study, we synthesized structural analogues of 1 to explore its skeletal structure-activity relationships and found that the C18 methyl group and the configuration of the C16-C17 double bond of 1 are important for the potent antiproliferative activity. Furthermore, we prepared a series of side-chain analogues of 1 by diversification of a late-stage intermediate of our total synthesis, and found that the triene side chain of 1 could be modified to some extent without significant loss of activity, provided a Lewis basic heteroatom is placed at the terminus.

Original languageEnglish
Pages (from-to)3442-3450
Number of pages9
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number21
DOIs
Publication statusPublished - 2013 Jun 7

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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