Total Synthesis and Absolute Stereochemistry of Pentenocin B, a Novel Interleukin-1β Converting Enzyme Inhibitor

Tsutomu Sugahara, Hayato Fukuda, Yoshiharu Iwabuchi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Four possible diastereomers of pentenocin B were synthesized in a stereocontrolled manner, and the first total synthesis of a natural enantiomer of (+)-pentenocin B unequivocally established the absolute stereochemistry to be 4S,5R,6R.

Original languageEnglish
Pages (from-to)1744-1747
Number of pages4
JournalJournal of Organic Chemistry
Volume69
Issue number5
DOIs
Publication statusPublished - 2004 Mar 5

ASJC Scopus subject areas

  • Organic Chemistry

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