Total Syntheses of Pyocyanin, Lavanducyanin, and Marinocyanins A and B

Haruki Kohatsu, Shogo Kamo, Shusuke Tomoshige, Kouji Kuramochi

Research output: Contribution to journalArticle

Abstract

Total syntheses of pyocyanin, lavanducyanin, and marinocyanins A and B have been accomplished. The N-substituted phenazin-1-one skeleton, a common framework of these natural products, was constructed through the oxidative condensation of pyrogallol with N-substituted benzene-1,2-diamine under an oxygen atmosphere in a single step. Regioselective bromination with N-bromosuccinimide at the C-2 position of N-alkylated phenazin-1-ones afforded brominated natural products.

Original languageEnglish
Pages (from-to)7311-7314
Number of pages4
JournalOrganic letters
Volume21
Issue number18
DOIs
Publication statusPublished - 2019 Sep 20
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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