Total Syntheses of (+)-Marrubiin and (-)-Marrulibacetal

Hiroyuki Yamakoshi, Yuki Sawayama, Yoshihiro Akahori, Marie Kato, Seiichi Nakamura

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

A stereoselective total synthesis of (+)-marrubiin has been accomplished starting from a chiral building block via the CyNH2-promoted Pauson-Khand reaction (PKR) followed by oxidative cleavage of the resultant cyclopentenone ring. Two successive oxidations and internal transacetalization culminated in the total synthesis of the antispasmodic labdane diterpenoid (-)-marrulibacetal.

Original languageEnglish
Pages (from-to)3430-3433
Number of pages4
JournalOrganic letters
Volume18
Issue number14
DOIs
Publication statusPublished - 2016 Jul 15
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Total Syntheses of (+)-Marrubiin and (-)-Marrulibacetal'. Together they form a unique fingerprint.

Cite this