Total syntheses of leuconodine B, melodinine E, and leuconoxine were accomplished via a divergent route. The [184.108.40.206]diazafenestrane skeleton was constructed from an indole-3-acetamide derivative via DMDO oxidation to hydroxylindolenine, TMSOTf/2,6-lutidine mediated cyclic aminal formation, and diastereoseletive ring-closing metathesis of a triene derivative.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry