Total syntheses of complanadines A and B

Le Zhao, Chihiro Tsukano, Eunsang Kwon, Yoshiji Takemoto, Masahiro Hirama

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Twice as nice: Total syntheses of dimeric alkaloids, (-)-complanadines A (1) and B (2), were achieved from (-)-lycodine. The unsymmetrical motif was assembled through direct arylation of the pyridine N-oxide. The absolute configuration and specific rotations of complanadines A and B were identified. Cbz=Benzyloxycarbonyl.

Original languageEnglish
Pages (from-to)1722-1725
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number6
DOIs
Publication statusPublished - 2013 Feb 4

Keywords

  • alkaloids
  • biomimetic synthesis
  • complanadine
  • direct arylation
  • total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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