Topographic differences in gastric micromucosal patterns observed by magnifying endoscopy with narrow band imaging

Masashi Kawamura, Shu Abe, Keisuke Oikawa, Shiho Terai, Masahiro Saito, Daisuke Shibuya, Katsuaki Kato, Takenobu Shimada, Noriya Uedo, Takayuki Masuda

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Background and Aim: The distributions and grades of Helicobacter pylori induced gastritis are known to vary among H. pylori-associated diseases. The aim of this study was to investigate the differences in distributions of gastric micromucosal structures observed by magnifying narrow band imaging (NBI) endoscopy among patients with different H. pylori-associated diseases. Methods: Ninety-five patients with active duodenal ulcers (n=24) and diffuse-type (n=24) and intestinal-type (n=47) early gastric cancers were enrolled. The magnified NBI findings were evaluated at the lesser and greater curvatures in the upper gastric corpus and were classified according to the modified A-B classification system. Biopsy specimens were also evaluated. Results: In a total of 190 areas observed with magnifying NBI, histological grading (inflammation, activity, atrophy and intestinal metaplasia) showed significant differences among the classified micromucosal patterns (P<0.001). Types B-1 and B-2, with mild atrophic changes and few areas of intestinal metaplasia, were seen mostly in the duodenal ulcers group. Types B-3 and A-1, with moderate atrophic changes, were seen in the diffuse-type early gastric cancers at the lesser curvature. Types A-1 and A-2, with severe atrophic change and a high frequency of intestinal metaplasia, were seen in the intestinal-type early gastric cancers at the lesser curvature. The prevalence of micromucosal structures differed significantly among the three groups both at the lesser and greater curvatures (P<0.001). Conclusions: Magnifying NBI endoscopy clearly revealed detailed micromorphological differences corresponding to the histology and endoscopic findings among patients with different H. pylori-associated diseases.

Original languageEnglish
Pages (from-to)477-483
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume26
Issue number3
DOIs
Publication statusPublished - 2011 Mar
Externally publishedYes

Keywords

  • Helicobacter pylori
  • Magnifying endoscopy
  • Narrow band imaging

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Topographic differences in gastric micromucosal patterns observed by magnifying endoscopy with narrow band imaging'. Together they form a unique fingerprint.

Cite this