Topical treatment of pulmonary aspergilloma by antifungals: Relationship between duration of the disease and efficacy of therapy

H. Yamada, S. Kohno, H. Koga, S. Maesaki, M. Kaku

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)

Abstract

Twelve patients with aspergilloma were treated with intracavitary or endobronchial administration of antifungals. Patients with successful therapy had significantly shorter mean duration of the disease course (3.6 months) than the less effective group (44.4 months, p<0.01). Minimal inhibitory concentrations of antifungal agents against isolated strains of aspergilli were considerably lower than estimated intracavitary concentrations of the antifungals. A pathologic examination suggested that the old mycetoma was for the most part comprised of dead mycelial cells, against which antifungal agents were not effective. However, clinical improvement was obtained, regardless of the roentgenographic improvement. Our study suggested that early diagnosis and therapy are recommended to achieve better therapeutic effect.

Original languageEnglish
Pages (from-to)1421-1425
Number of pages5
JournalChest
Volume103
Issue number5
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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