Tooth regenerative therapy: Tooth tissue repair and whole tooth replacement

M. Oshima, K. Ishida, R. Morita, M. Saito, T. Tsuji

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Oral function and associated health issues are impaired by irreversible dental problems, including dental caries and periodontal disease. Tooth regenerative therapy for tissue repair and whole tooth replacement are novel treatment approaches with the potential to fully recover tooth function. The dental tissue repair method uses stem cells and cytokines but not artificial materials to promote odontogenesis. Whole tooth replacement therapy as a form of bioengineered organ replacement is regarded as an important model system for the development of this concept. This article reviews recent findings and technologies underpinning tooth regenerative therapy.

Original languageEnglish
Title of host publicationEncyclopedia of Biomedical Engineering
PublisherElsevier
Pages686-695
Number of pages10
Volume1-3
ISBN (Electronic)9780128051443
ISBN (Print)9780128048290
DOIs
Publication statusPublished - 2018 Jan 1
Externally publishedYes

Keywords

  • Bioengineered tooth
  • Bioengineered tooth germ
  • Bioengineered tooth unit
  • Cell compartmentalization
  • Epithelial-mesenchymal interaction
  • Occlusion
  • Organ germ method
  • Organ replacement regenerative therapy
  • Tooth development
  • Tooth physiological function
  • Tooth regeneration

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Oshima, M., Ishida, K., Morita, R., Saito, M., & Tsuji, T. (2018). Tooth regenerative therapy: Tooth tissue repair and whole tooth replacement. In Encyclopedia of Biomedical Engineering (Vol. 1-3, pp. 686-695). Elsevier. https://doi.org/10.1016/B978-0-12-801238-3.00040-4