Tooth regenerative therapy: Tooth tissue repair and whole tooth replacement

M. Oshima, K. Ishida, R. Morita, M. Saito, T. Tsuji

Research output: Chapter in Book/Report/Conference proceedingChapter


Oral function and associated health issues are impaired by irreversible dental problems, including dental caries and periodontal disease. Tooth regenerative therapy for tissue repair and whole tooth replacement are novel treatment approaches with the potential to fully recover tooth function. The dental tissue repair method uses stem cells and cytokines but not artificial materials to promote odontogenesis. Whole tooth replacement therapy as a form of bioengineered organ replacement is regarded as an important model system for the development of this concept. This article reviews recent findings and technologies underpinning tooth regenerative therapy.

Original languageEnglish
Title of host publicationEncyclopedia of Biomedical Engineering
Number of pages10
ISBN (Electronic)9780128051443
ISBN (Print)9780128048290
Publication statusPublished - 2019 Jan 1
Externally publishedYes


  • Bioengineered tooth
  • Bioengineered tooth germ
  • Bioengineered tooth unit
  • Cell compartmentalization
  • Epithelial-mesenchymal interaction
  • Occlusion
  • Organ germ method
  • Organ replacement regenerative therapy
  • Tooth development
  • Tooth physiological function
  • Tooth regeneration

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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