Tocotrienol levels in various tissues of sprague-dawley rats after intragastric administration of tocotrienols

Masaaki Okabe, Mariko Oji, Ikuo Ikeda, Hirofumi Tachibana, Koji Yamada

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A tocotrienol (T3) mixture was intragastricaly administered to Sprague-Dawley rats, and the T3 levels in various tissues were measured 0, 4, 8 and 24 hr after the administration. In blood clots, brain, thymus, testes, vice-testes and muscles, T3 homologues were not detected at all. In epididymal adipose, renal adipose, subcutaneous adipose and brown adipose tissues and in the heart, the T3 levels were maintained or increased for 24 hr after the administration. In the serum, liver, mesenteric lymph node, spleen and lungs, the T3 levels were highest 8 hr after the T3 administration. These results suggest that the distribution and metabolism of T3 in the rat vary considerably among different tissues.

Original languageEnglish
Pages (from-to)1768-1771
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume66
Issue number8
DOIs
Publication statusPublished - 2002 Jan 1

Keywords

  • Tocopherol
  • Tocotrienol

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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