TNF Receptor-Associated Factor 5 Limits the Induction of Th2 Immune Responses

Takanori So, Shahram Salek-Ardakani, Hiroyasu Nakano, Carl F. Ware, Michael Croft

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The TNF receptor-associated factor (TRAF) family of molecules acts as adapter proteins for signaling pathways initiated by several members of the TNF receptor (TNFR) superfamily. TRAF5-/- animals are viable and have normal development of the immune system despite interacting with several TNFR family members. A clear role for TRAF5 has yet to emerge. OX40 (CD134) interacts with TRAFS, suggesting that this pathway could be involved in regulating T cell differentiation into Th1 or Th2 cells. In tissue culture, OX40 stimulation of TRAF5-/- T cells resulted in a pronounced Th2 phenotype with elevated levels of IL-4 and IL-5. Similarly, in vivo immunization with protein in adjuvant in the presence of an agonist anti-OX40 Ab resulted in enhanced Th2 development in TRAF5-/- mice. Additionally, lung inflammation induced by T cells, which is critically controlled by OX40, was more pronounced in TRAF5-/- mice, characterized by higher levels of Th2 cytokines. These results suggest that TRAF5 can limit the induction of Th2 responses, and that TRAF5 can play a role in modulating responses driven by OX40 costimulation.

Original languageEnglish
Pages (from-to)4292-4297
Number of pages6
JournalJournal of Immunology
Volume172
Issue number7
DOIs
Publication statusPublished - 2004 Apr 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    So, T., Salek-Ardakani, S., Nakano, H., Ware, C. F., & Croft, M. (2004). TNF Receptor-Associated Factor 5 Limits the Induction of Th2 Immune Responses. Journal of Immunology, 172(7), 4292-4297. https://doi.org/10.4049/jimmunol.172.7.4292