Tissue tropism and species specificity of poliovirus infection

Akio Nomoto, Satoshi Koike, Junken Aoki

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)


Paralytic poliomyelitis is caused by the destruction of neurons in the central nervous system during the lytic replication of poliovirus. The human gene for the poliovirus receptor has been cloned recently, and transgenic mice generated that are susceptible to this virus. This has allowed the critical amino acids that determine the specificity of poliovirus to be identified.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalTrends in Microbiology
Issue number2
Publication statusPublished - 1994 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology


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