Tissue tropism and species specificity of poliovirus infection

Akio Nomoto; Satoshi Koike; Junken Aoki

doi:10.1016/0966-842X(94)90125-2

Tissue tropism and species specificity of poliovirus infection

Akio Nomoto, Satoshi Koike, Junken Aoki

Research output: Contribution to journal › Review article › peer-review

26 Citations (Scopus)

Abstract

Paralytic poliomyelitis is caused by the destruction of neurons in the central nervous system during the lytic replication of poliovirus. The human gene for the poliovirus receptor has been cloned recently, and transgenic mice generated that are susceptible to this virus. This has allowed the critical amino acids that determine the specificity of poliovirus to be identified.

Original language	English
Pages (from-to)	47-51
Number of pages	5
Journal	Trends in Microbiology
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/0966-842X(94)90125-2
Publication status	Published - 1994 Jan 1
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

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10.1016/0966-842X(94)90125-2

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abstract = "Paralytic poliomyelitis is caused by the destruction of neurons in the central nervous system during the lytic replication of poliovirus. The human gene for the poliovirus receptor has been cloned recently, and transgenic mice generated that are susceptible to this virus. This has allowed the critical amino acids that determine the specificity of poliovirus to be identified.",

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