Abstract
Paralytic poliomyelitis is caused by the destruction of neurons in the central nervous system during the lytic replication of poliovirus. The human gene for the poliovirus receptor has been cloned recently, and transgenic mice generated that are susceptible to this virus. This has allowed the critical amino acids that determine the specificity of poliovirus to be identified.
Original language | English |
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Pages (from-to) | 47-51 |
Number of pages | 5 |
Journal | Trends in Microbiology |
Volume | 2 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1994 Jan 1 |
Externally published | Yes |
ASJC Scopus subject areas
- Microbiology
- Microbiology (medical)
- Infectious Diseases
- Virology