Tissue remin content in superficial, midcortical, and juxtamedullary afferent arterioles in rabbits

Noboru Nushiro, Keishi Abe, Seiichi Misawa, Sadayoshi Ito, Kaoru Yoshinaga

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Tissue renin content within the kidney decreases from outer to inner cortex. However, it is not known whether this gradient is due to a decrease in the number of afferent arterioles from the outer to inner cortex or the decrease in renin content per afferent arteriole. Furthermore, it is still controversial whether sodium depletion increases or decreases this gradient. According to Taugner et al., sodium depletion induces the extension of renin positive part of afferent arterioles from vascular pole toward interlobular artery. Since the length of extension may differ among superficial, midcortical, and juxtamedullary afferent arterioles, the observed gradient may vary depending on whether the entire afferent arteriole or only the vascular pole is examined. In the present study, we microdissected the entireafferent arterioles from superficial, middle, and juxtamedullary cortex of rabbit kidney, and examined tissue renin content. We studied: 1. whether tissue renin content per afferent arteriole decreases from the outer to inner cortex. 2. whether sodium depletion affects the gradient of tissue renin content within the cortex. In result, we reached the conclusions, as follows: 1. Tissue renin content per afferent arteriole decreases steeply from superficial to midcorticalto juxtamedullary afferent arterioles. 2. The absolute difference in renin content among the three types of afferent arterioles becomes greater during sodium depletion. The internephron heterogeneity of tissue renin content may contribute to functional heterogeneity.

Original languageEnglish
Pages (from-to)1107-1111
Number of pages5
JournalThe Japanese Journal Of Nephrology
Volume34
Issue number10
DOIs
Publication statusPublished - 1992

Keywords

  • afferent arteriole
  • internephron heterogeneity
  • microdissection
  • renin content

ASJC Scopus subject areas

  • Nephrology

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