Tissue heterogeneity of EGFR mutation in lung adenocarcinoma

Akira Sakurada, Humberto Lara-Guerra, Ni Liu, Frances A. Shepherd, Ming Sound Tsao

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


Tissue heterogeneity of EGFR gene mutation was studied in 10 formalin-fixed paraffin-embedded (FFPE) samples from four cases that demonstrated EGFR mutations in snap-frozen samples. EGFR mutations identical to those in frozen sample were demonstrated in 8 of 10 FFPE samples by direct sequencing and in 9 of 10 by fragment length analysis, but an exon-19 deletion mutation could not be identified in one FFPE sample analyzed by both techniques, despite multiple repeated assays. This suggests that some tumors may demonstrate intratumoral heterogeneity for the occurrence of EGFR mutation.

Original languageEnglish
Pages (from-to)527-529
Number of pages3
JournalJournal of Thoracic Oncology
Issue number5
Publication statusPublished - 2008 May
Externally publishedYes


  • Epidermal growth factor receptor
  • Heterogeneity
  • Mutation
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine


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