Tissue Doppler echocardiography for predicting arterial stiffness assessed by cardio-ankle vascular index

Hisashi Masugata, Shoichi Senda, Fuminori Goda, Ayumu Yamagami, Hiroyuki Okuyama, Takeaki Kohno, Naohisa Hosomi, Kazushi Yukiiri, Takahisa Noma, Hideyasu Kiyomoto, Koji Murao, Akira Nishiyama, Masakazu Kohno

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

It has been reported that left ventricular (LV) diastolic functional parameters assessed by conventional Doppler echocardiography, which measures blood flow velocities in cardiac cavity, correlate with arterial stiffness assessed by the cardio-ankle vascular index (CAVI) and are markers for increased risk of cardiovascular events. Recently, tissue Doppler echocardiography, which measures velocities of regional cardiac wall, has been widely used for assessment of LV diastolic function because of more accuracy than conventional Doppler echocardiography. However, there are no data regarding the ability of tissue Doppler echocardiography for predicting increased arterial stiffness. We investigated the correlation of LV diastolic functional parameters from tissue Doppler echocardiography to CAVI in order to clarify the ability of tissue Doppler echocardiography for predicting increased arterial stiffness in patients with cardiovascular risk factors. Enrolled in the study were 70 patients (69 ± 8 years) who had no overt heart disease, but had at least on of hypertension, diabetes, and dyslipidemia. The peak early diastolic mitral annular velocity (E') was measured as an index of LV diastolic function using tissue Doppler echocardiography. The E' was correlated withCAVI (r = -0.518, p < 0.001). The optimal cut-off point the detection of abnormal CAVI (≥ 8.81) was 5.6 cm.s for E' (sensitivity 71%, specificity 71%). The decrease in E' correlated with both LV diastolic dysfunction and increased arterial stiffness. Therefore, the LV diastolic dysfunction assessed by tissue Doppler echocardiography may be useful for predicting increased arterial stiffness and cardiovascular events in the patients with risk factors.

Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalTohoku Journal of Experimental Medicine
Volume217
Issue number2
DOIs
Publication statusPublished - 2009

Keywords

  • Arterial stiffness
  • Cardiovascular risk factor
  • Echocardiography
  • Left ventricular diastolic function

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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