Tissue distribution of tetrodotoxin in the red-spotted newt Notophthalmus viridescens

Dietrich Mebs, Osamu Arakawa, Mari Yotsu-Yamashita

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

High levels of tetrodotoxin (TTX) and of its analogue 6-epi-tetrodotoxin have been detected in skin and liver extracts of the red-spotted newt Notophthalmus viridescens assayed by a post-column fluorescent-HPLC system. Using a monoclonal antibody-based immunoenzymatic technique, TTX was localized in the granular glands of the epidermis as well as in the muscle layer between the muscle fibres, but also in most organs suggesting that TTX is stored in the whole body of the newt and is secreted by skin glands.

Original languageEnglish
Pages (from-to)1353-1357
Number of pages5
JournalToxicon
Volume55
Issue number7
DOIs
Publication statusPublished - 2010 Jun 1

Keywords

  • 6-epi-tetrodotoxin
  • Monoclonal antibody
  • Newt
  • Notophthalmus viridescens
  • Organ distribution
  • Tetrodotoxin

ASJC Scopus subject areas

  • Toxicology

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