Using Southern blot analysis it is demonstrated that S-100α and β genes were found as single copies in the rat genome. S-100α mRNA was not found at all in rat brain during the developmental period, but it was slightly detectable in muscle and kidney. S-100β mRNA was detected in rat brain, and its mRNA level increased during the developmental period. The different localizations of the subunits may be due to the specific expression of each gene in various tissues.
- S-100 protein
- Southern/Northern blot hybridization
- Tissue distribution
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience