TiO2 microspheres containing magnetic nanoparticles for intra-arterial hyperthermia

Hiroyasu Kanetaka, Gengci Liu, Zhixia Li, Toshiki Miyazaki, Maiko Furuya, Tada Aki Kudo, Masakazu Kawashita

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Magnetic microspheres measuring 15–35 µm in diameter are believed to be useful for intra-arterial hyperthermia. In this study, we attempted to prepare titanium dioxide (TiO2) microspheres containing magnetic nanoparticles (MNPs). MNP-containing TiO2 microspheres with diameters of approximately 30 µm were successfully obtained by sol–gel reaction of titanium tetraisopropoxide in a water-in-oil emulsion with added cosurfactant of 1-butanol and subsequent heat treatment at 200°C. The microspheres showed ferrimagnetism owing to high content of MNPs in approximately 60 wt % and had a low-crystalline TiO2 matrix. Furthermore, the agar phantom was heated to above 43°C after approximately 1 min under an alternating magnetic field of 100 kHz and 300 Oe and showed in vitro biocompatibility similar to that of MNP-free TiO2 microspheres.

Original languageEnglish
Pages (from-to)2308-2314
Number of pages7
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Issue number8
Publication statusPublished - 2017 Nov


  • TiO
  • hyperthermia
  • magnetic nanoparticles
  • microspheres

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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