Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation

Satoshi Omori, Misato Tsugita, Yasuto Hoshikawa, Masanobu Morita, Fumiya Ito, Shin Ichiro Yamaguchi, Qilin Xie, Osamu Noyori, Tomoya Yamaguchi, Ayato Takada, Tatsuya Saitoh, Shinya Toyokuni, Hisaya Akiba, Shigekazu Nagata, Kengo Kinoshita, Masafumi Nakayama

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Needle-like multi-walled carbon nanotubes (MWCNTs) are engulfed by macrophages, which cause inflammation and asbestosis-like pathogenesis in rodents; however, how macrophages recognize MWCNTs remains unclear. Omori et al. demonstrate that Tim4 recognizes MWCNTs through aromatic-aromatic interactions and mediates macrophage phagocytosis leading to granulomas.

Original languageEnglish
Article number108734
JournalCell Reports
Volume34
Issue number6
DOIs
Publication statusPublished - 2021 Feb 9

Keywords

  • Caspase-1
  • IL-1β
  • Tim-1
  • Tim-4
  • molecular dynamics simulation
  • nanomaterials

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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