Ti(III)-catalyzed radical cyclization of 6,7-epoxygeranyl acetate

Shinichiro Fuse, Malcoln Hanochi, Takayuki Doi, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

The reductive cyclization of epoxygeranyl acetate (1) was investigated using a catalytic amount of Cp2TiCl with various additives. The newly developed Cp2TiCl-Mn-lutidine·HCl-BEt3 system was found to be as effective as the reported stoichiometric system to afford the cyclized dehydro products 4 and 5 with 72% selectivity.

Original languageEnglish
Pages (from-to)1961-1963
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number9
DOIs
Publication statusPublished - 2004 Feb 23
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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