Tight linkage of the ret proto-oncogene with the multiple endocrine neoplasia type 2A locus

Masayuki Yamamoto, Tetsuro Miki, Norifumi Tanaka, Akihiro Miya, Eisei Shin, Katsu Karakawa, Tetsuro Kobayashi, Tomoko Tahira, Yukihito Ishizaka, Fumio Itoh, Minako Nagao, Takesada Mori, Shin Ichiro Takai

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


The ret proto-oncogene has been mapped to 10q11.2 near the MEN2A locus by in situ hybridization. We carried out a linkage study of Japanese multiple endocrine neoplasia type 2A (MEN2A) families using a cosmid clone containing the ret proto-oncogene as probe. Two polymorphic alleles (A1 and A2) could be detected by digesting DNA with EcoRl: allele A1 was detected as a 10 kb fragment and A2 as 5.4 and 4.6 kb fragments. Of 11 Japanese MEN2A families analysed, four were informative, and the maximum lod score was 4.23 at a recombination fraction of 0.00. This result suggests the ret proto-oncogene to be close to the MEN2A gene and therefore possibly to be a useful DNA marker for cloning the latter.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalJapanese journal of clinical oncology
Issue number3
Publication statusPublished - 1991 Jun
Externally publishedYes


  • Linkage
  • Lod score
  • MEN2A
  • RELP (Restriction Fragment Length Polymorphism)
  • Ret proto-oncogene

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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