Thyroid hormone transporters: Recent advances

Takaaki Abe, Takehiro Suzuki, Michiaki Unno, Taro Tokui, Sadayoshi Ito

Research output: Contribution to journalReview articlepeer-review

93 Citations (Scopus)

Abstract

Thyroid hormones, being hydrophobic, were thought to enter target cell membranes by passive diffusion. However, recent studies have documented the existence of numerous organic anion transport systems, about half of which also transport thyroid hormones into (and possibly out of) a variety of target cells. Several of the genes encoding thyroid hormone transporters have been characterized by means of molecular approaches. Here, we discuss the classification of thyroid hormone transporters, with emphasis on how they are influenced by their ionic milieu and what their symported organic anions are.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume13
Issue number5
DOIs
Publication statusPublished - 2002 Jul
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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