Thyroid hormone suppression of hepatic levels of phenobarbital-inducible P-450b AND P-450e and other neonatal P-450S in hypophysectomized rats

Yasushi Yamazoe, Norie Murayama, Miki Shimada, Ryuichi Kato

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    44 Citations (Scopus)

    Abstract

    Mechanism of developmental suppression of cytochrome P-450 (P-450) in rat livers was studied using Western blots. The contents of phenobarbital (PB)-inducible P-450b and P-450e, expressed constitutively in livers, were higher in neonate than in adult rats. The contents were also 10∼50 fold higher in hypophysectomized than in intact adult male rats. Administration of L-triiodothyronine (T3, 50 μg/kg) or human growth hormone (4U/kg) reversed almost completely the increased amounts of P-450b and P-450e. T3-induced suppression was also observed on two other neonatal P-450s (P-4506β-1 and P-448-H), which are expressed in neonatal periods in livers. The postnatal developmental profiles of hepatic P-450b were correlated inversely with that of serum free T3 level in rats reported (Walker et al. (1980) Pediat. Res. 14, 249). These results suggest, in addition to pituitary growth hormone (Yamazoe et al. (1987) J. Biol. Chem. 262, 7423), the possible involvement of T3 on the suppressive regulation of PB-inducible and other neonatal P-450s.

    Original languageEnglish
    Pages (from-to)609-614
    Number of pages6
    JournalBiochemical and biophysical research communications
    Volume160
    Issue number2
    DOIs
    Publication statusPublished - 1989 Apr 28

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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