Thrombotic thrombocytopenic purpura complicated with hypereosinophilic syndrome

Hiroto Ohguchi, Tomohiro Sugawara, Hideo Harigae

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11 Citations (Scopus)


An 80-year-old woman was referred to our hospital because of eosinophilia and thrombocytopenia. She presented with persistent pruritus and cough. Laboratory examinations showed persistent eosinophilia, and there was no underlying cause, consistent with hypereosinophilic syndrome (HES). After admission, she developed a neurological deficit, and microangiopathic hemolytic anemia. She was diagnosed with thrombotic thrombocytopenic purpura (TTP) and successfully treated with corticosteroids and plasmapheresis. Although TTP has been described in association with pregnancy, cancer, collagen diseases, infection, and drug intake, hypereosinophilia is not a well-documented cause of this disorder. To our knowledge, this is only the second case of TTP with HES, proved to be caused by ADAMTS13 inhibitor.

Original languageEnglish
Pages (from-to)1687-1690
Number of pages4
JournalInternal Medicine
Issue number18
Publication statusPublished - 2009


  • Eosinophilia
  • Hypereosinophilic syndrome
  • Thrombotic microangiopathy
  • Thrombotic thrombocytopenic purpura

ASJC Scopus subject areas

  • Internal Medicine


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