Three novel single nucleotide polymorphisms (SNPs) of the CYP2B6 gene in Japanese individuals.

Masahiro Hiratsuka, Yudai Hinai, Yumiko Konno, Hisayoshi Nozawa, Shoetsu Konno, Michinao Mizugaki

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We sequenced all exons and exon-intron junctions of the CYP2B6 gene from 200 Japanese individuals. We found three novel single nucleotide polymorphisms (SNPs) (1375A>G, 1427G>A and 1454A>T) causing amino acid substitutions (Met(459)Val, Gly(476)Asp and Gln(485)Leu in exon 9), respectively. The detected SNP was as follows: 1) SNP, 031226Hiratsuka01; GENE NAME, CYP2B6; ACCESSION NUMBER, AC023172; LENGTH, 25 base; 5'-CAGAACTTCTCCA/GTGGCCAGCCCCG-3'. 2) SNP, 031226Hiratsuka02; GENE NAME, CYP2B6; ACCESSION NUMBER, AC023172; LENGTH, 25 base; 5'-CCCAGGAGTGTGG/ATGTGGGCAAAAT-3'. 3) SNP, 031226Hiratsuka03; GENE NAME, CYP2B6; ACCESSION NUMBER, AC023172; LENGTH, 25 base; 5'-CCCCAACATACCA/TGATCCGCTTCCT-3'.

Original languageEnglish
Pages (from-to)155-158
Number of pages4
JournalDrug metabolism and pharmacokinetics
Volume19
Issue number2
DOIs
Publication statusPublished - 2004 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

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