Three novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals.

Yoshiyuki Hanzawa, Takamitsu Sasaki, Masahiro Hiratsuka, Masaaki Ishikawa, Michinao Mizugaki

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

We analyzed all nine exons and exon-intron junctions of the CYP2S1 gene in 200 Japanese individuals and identified the following three novel single nucleotide polymorphisms (SNPs): 4612G>A (Glu147Glu) in exon 3, 5478C>T (Leu230Leu) and 5479T>G (Leu230Arg, CYP2S1*5A) in exon 5. The allele frequencies were 0.013 for 4612G>A, 0.058 for 5478C>T, and 0.003 for 5479T>G. In addition, a known SNP 1324C>G (Pro74Pro) was detected at a frequency of 0.300.

Original languageEnglish
Pages (from-to)136-140
Number of pages5
JournalDrug metabolism and pharmacokinetics
Volume22
Issue number2
DOIs
Publication statusPublished - 2007 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

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