Three-membered ring sesquiterpenoids with NGF-potentiating activity from the roots of Valeriana fauriei

Yuanqiang Guo, Jing Xu, Yushan Li, Tohru Yamakuni, Yasushi Ohizumi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Three novel three-membered ring sesquiterpenoids, named kissoone A(1), kissoone B (2), and its acetylated product, kissoone C (3), were isolated from the roots of Valeriana fauriei. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 3 showed enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC 12D cells.

Original languageEnglish
Pages (from-to)373-375
Number of pages3
JournalPlanta Medica
Volume72
Issue number4
DOIs
Publication statusPublished - 2006 Mar

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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