Three-Dimensional Structure of Mucosal and Submucosal Lymphatics in Rat Small Intestine

Kouhei Fukushima, Iwao Sasaki, Takayuki Masuda, Hiroshi Nagura, Hiroo Naito, Yuji Funayama, Seiki Matsuno

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


The organization of the lymphatic system in the rat ileum was investigated by the three-dimensional reconstruction using serial sections after dilatation of lymphatics. This method has an advantage to exclude possible artifacts in the conventional corrosion cast method. The villus possessed several lacteals and connected to each other by sinus. Two or three perpendicularly oriented lymphatics descended and led into the submucosal lymphatic network. In mucosa and submucosa, no valvular structure was detected. This study confirmed the voluminous lacteals and fine network structure of lymphatics in submucosa without valves, suggesting great potential to keep lymph and to drain soluble factors and cellular components.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalTohoku Journal of Experimental Medicine
Issue number1
Publication statusPublished - 1998 May


  • Lymphatic vessel
  • Small intestine
  • Three dimensional reconstruction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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