Three-dimensional Simulation of Blood Flow in Malaria Infection

Yohsuke Imai, H. Kondo, Takuji Ishikawa, C. T. Lim, K. Tsubota, Takami Yamaguchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We propose a numerical method for simulating three-dimensional hemodynamics arising from malariainfection. Malaria-infected red blood cells (IRBCs) become stiffer and develop the property of cytoadherent and resetting. To clarify the mechanism of microvascular obstruction in malaria, we need to understand the changes of hemodynamics, involving interaction between IRBC, healthy RBCs, and endothelial cells. In the proposed model, all the components of blood are represented by a finite number of particles. The membrane of RBCs is expressed by two-dimensional network. Malaria parasites inside the RBC are represented by solid objects. The motion of each particle is described by the conservation laws of mass and momentum for incompressible fluid. We examine several numerical tests, involving the stretching of IRBCs, and flow in narrow channels, to validate our model. The obtained results agree well with the experimental results. Our method would be helpful for further understandings of pathology of malaria-infection.

Original languageEnglish
Title of host publication13th International Conference on Biomedical Engineering - ICBME 2008
Pages2244-2247
Number of pages4
DOIs
Publication statusPublished - 2009 Dec 1
Event13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
Duration: 2008 Dec 32008 Dec 6

Publication series

NameIFMBE Proceedings
Volume23
ISSN (Print)1680-0737

Other

Other13th International Conference on Biomedical Engineering, ICBME 2008
CountrySingapore
Period08/12/308/12/6

Keywords

  • Infected red blood cell
  • computational fluid dynamics
  • hemodynamics
  • numerical modeling

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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