Three-dimensional Simulation of Blood Flow in Malaria Infection

Yohsuke Imai; H. Kondo; Takuji Ishikawa; C. T. Lim; K. Tsubota; Takami Yamaguchi

doi:10.1007/978-3-540-92841-6_562

Three-dimensional Simulation of Blood Flow in Malaria Infection

Yohsuke Imai, H. Kondo, Takuji Ishikawa, C. T. Lim, K. Tsubota, Takami Yamaguchi

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

We propose a numerical method for simulating three-dimensional hemodynamics arising from malariainfection. Malaria-infected red blood cells (IRBCs) become stiffer and develop the property of cytoadherent and resetting. To clarify the mechanism of microvascular obstruction in malaria, we need to understand the changes of hemodynamics, involving interaction between IRBC, healthy RBCs, and endothelial cells. In the proposed model, all the components of blood are represented by a finite number of particles. The membrane of RBCs is expressed by two-dimensional network. Malaria parasites inside the RBC are represented by solid objects. The motion of each particle is described by the conservation laws of mass and momentum for incompressible fluid. We examine several numerical tests, involving the stretching of IRBCs, and flow in narrow channels, to validate our model. The obtained results agree well with the experimental results. Our method would be helpful for further understandings of pathology of malaria-infection.

Original language	English
Title of host publication	13th International Conference on Biomedical Engineering - ICBME 2008
Pages	2244-2247
Number of pages	4
DOIs	https://doi.org/10.1007/978-3-540-92841-6_562
Publication status	Published - 2009 Dec 1
Event	13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore Duration: 2008 Dec 3 → 2008 Dec 6

Publication series

Name	IFMBE Proceedings
Volume	23
ISSN (Print)	1680-0737

Other

Other	13th International Conference on Biomedical Engineering, ICBME 2008
Country	Singapore
Period	08/12/3 → 08/12/6

Keywords

Infected red blood cell
computational fluid dynamics
hemodynamics
numerical modeling

ASJC Scopus subject areas

Bioengineering
Biomedical Engineering

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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Imai, Y, Kondo, H, Ishikawa, T, Lim, CT, Tsubota, K & Yamaguchi, T 2009, Three-dimensional Simulation of Blood Flow in Malaria Infection. in 13th International Conference on Biomedical Engineering - ICBME 2008. IFMBE Proceedings, vol. 23, pp. 2244-2247, 13th International Conference on Biomedical Engineering, ICBME 2008, Singapore, 08/12/3. https://doi.org/10.1007/978-3-540-92841-6_562

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title = "Three-dimensional Simulation of Blood Flow in Malaria Infection",

abstract = "We propose a numerical method for simulating three-dimensional hemodynamics arising from malariainfection. Malaria-infected red blood cells (IRBCs) become stiffer and develop the property of cytoadherent and resetting. To clarify the mechanism of microvascular obstruction in malaria, we need to understand the changes of hemodynamics, involving interaction between IRBC, healthy RBCs, and endothelial cells. In the proposed model, all the components of blood are represented by a finite number of particles. The membrane of RBCs is expressed by two-dimensional network. Malaria parasites inside the RBC are represented by solid objects. The motion of each particle is described by the conservation laws of mass and momentum for incompressible fluid. We examine several numerical tests, involving the stretching of IRBCs, and flow in narrow channels, to validate our model. The obtained results agree well with the experimental results. Our method would be helpful for further understandings of pathology of malaria-infection.",

keywords = "Infected red blood cell, computational fluid dynamics, hemodynamics, numerical modeling",

author = "Yohsuke Imai and H. Kondo and Takuji Ishikawa and Lim, {C. T.} and K. Tsubota and Takami Yamaguchi",

year = "2009",

month = dec,

day = "1",

doi = "10.1007/978-3-540-92841-6_562",

language = "English",

isbn = "9783540928409",

series = "IFMBE Proceedings",

pages = "2244--2247",

booktitle = "13th International Conference on Biomedical Engineering - ICBME 2008",

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T1 - Three-dimensional Simulation of Blood Flow in Malaria Infection

AU - Imai, Yohsuke

AU - Kondo, H.

AU - Ishikawa, Takuji

AU - Lim, C. T.

AU - Tsubota, K.

AU - Yamaguchi, Takami

PY - 2009/12/1

Y1 - 2009/12/1

N2 - We propose a numerical method for simulating three-dimensional hemodynamics arising from malariainfection. Malaria-infected red blood cells (IRBCs) become stiffer and develop the property of cytoadherent and resetting. To clarify the mechanism of microvascular obstruction in malaria, we need to understand the changes of hemodynamics, involving interaction between IRBC, healthy RBCs, and endothelial cells. In the proposed model, all the components of blood are represented by a finite number of particles. The membrane of RBCs is expressed by two-dimensional network. Malaria parasites inside the RBC are represented by solid objects. The motion of each particle is described by the conservation laws of mass and momentum for incompressible fluid. We examine several numerical tests, involving the stretching of IRBCs, and flow in narrow channels, to validate our model. The obtained results agree well with the experimental results. Our method would be helpful for further understandings of pathology of malaria-infection.

AB - We propose a numerical method for simulating three-dimensional hemodynamics arising from malariainfection. Malaria-infected red blood cells (IRBCs) become stiffer and develop the property of cytoadherent and resetting. To clarify the mechanism of microvascular obstruction in malaria, we need to understand the changes of hemodynamics, involving interaction between IRBC, healthy RBCs, and endothelial cells. In the proposed model, all the components of blood are represented by a finite number of particles. The membrane of RBCs is expressed by two-dimensional network. Malaria parasites inside the RBC are represented by solid objects. The motion of each particle is described by the conservation laws of mass and momentum for incompressible fluid. We examine several numerical tests, involving the stretching of IRBCs, and flow in narrow channels, to validate our model. The obtained results agree well with the experimental results. Our method would be helpful for further understandings of pathology of malaria-infection.

KW - Infected red blood cell

KW - computational fluid dynamics

KW - hemodynamics

KW - numerical modeling

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U2 - 10.1007/978-3-540-92841-6_562

DO - 10.1007/978-3-540-92841-6_562

M3 - Conference contribution

AN - SCOPUS:84891956213

SN - 9783540928409

T3 - IFMBE Proceedings

SP - 2244

EP - 2247

BT - 13th International Conference on Biomedical Engineering - ICBME 2008

T2 - 13th International Conference on Biomedical Engineering, ICBME 2008

Y2 - 3 December 2008 through 6 December 2008

ER -

Three-dimensional Simulation of Blood Flow in Malaria Infection

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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