TY - GEN
T1 - Three-dimensional Simulation of Blood Flow in Malaria Infection
AU - Imai, Yohsuke
AU - Kondo, H.
AU - Ishikawa, Takuji
AU - Lim, C. T.
AU - Tsubota, K.
AU - Yamaguchi, Takami
PY - 2009/12/1
Y1 - 2009/12/1
N2 - We propose a numerical method for simulating three-dimensional hemodynamics arising from malariainfection. Malaria-infected red blood cells (IRBCs) become stiffer and develop the property of cytoadherent and resetting. To clarify the mechanism of microvascular obstruction in malaria, we need to understand the changes of hemodynamics, involving interaction between IRBC, healthy RBCs, and endothelial cells. In the proposed model, all the components of blood are represented by a finite number of particles. The membrane of RBCs is expressed by two-dimensional network. Malaria parasites inside the RBC are represented by solid objects. The motion of each particle is described by the conservation laws of mass and momentum for incompressible fluid. We examine several numerical tests, involving the stretching of IRBCs, and flow in narrow channels, to validate our model. The obtained results agree well with the experimental results. Our method would be helpful for further understandings of pathology of malaria-infection.
AB - We propose a numerical method for simulating three-dimensional hemodynamics arising from malariainfection. Malaria-infected red blood cells (IRBCs) become stiffer and develop the property of cytoadherent and resetting. To clarify the mechanism of microvascular obstruction in malaria, we need to understand the changes of hemodynamics, involving interaction between IRBC, healthy RBCs, and endothelial cells. In the proposed model, all the components of blood are represented by a finite number of particles. The membrane of RBCs is expressed by two-dimensional network. Malaria parasites inside the RBC are represented by solid objects. The motion of each particle is described by the conservation laws of mass and momentum for incompressible fluid. We examine several numerical tests, involving the stretching of IRBCs, and flow in narrow channels, to validate our model. The obtained results agree well with the experimental results. Our method would be helpful for further understandings of pathology of malaria-infection.
KW - Infected red blood cell
KW - computational fluid dynamics
KW - hemodynamics
KW - numerical modeling
UR - http://www.scopus.com/inward/record.url?scp=84891956213&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891956213&partnerID=8YFLogxK
U2 - 10.1007/978-3-540-92841-6_562
DO - 10.1007/978-3-540-92841-6_562
M3 - Conference contribution
AN - SCOPUS:84891956213
SN - 9783540928409
T3 - IFMBE Proceedings
SP - 2244
EP - 2247
BT - 13th International Conference on Biomedical Engineering - ICBME 2008
T2 - 13th International Conference on Biomedical Engineering, ICBME 2008
Y2 - 3 December 2008 through 6 December 2008
ER -
