Abstract
An efficient and regioselective synthesis of polysubstituted benzene derivatives was achieved via multicomponent reaction of a substituted cyclopropenone acetal and two alkyne molecules. The synthesis utilizes cyclopentadienone acetal as an intermediate and enables regioselective [2+2+2] assembly of the three-components into a benzene ring. A variety of polysubstituted benzene derivatives of synthetic and structural interest have been synthesized.
Original language | English |
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Pages (from-to) | 11449-11455 |
Number of pages | 7 |
Journal | Tetrahedron |
Volume | 61 |
Issue number | 48 |
DOIs | |
Publication status | Published - 2005 Nov 28 |
Keywords
- Cyclopentadiene
- Cyclopropene
- Diels-Alder reaction
- Polysubstituted benzene
- Three-component [2+2+2] synthesis
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry