Three cases of kindred with familial breast cancer in which carrier detection by BRCA gene testing was performed on family members

Tadashi Nomizu; Takeshi Sakuma; Mutsuo Yamada; Masami Matsuzaki; Naoto Katagata; Fumiaki Watanabe; Mitsuhiro Nihei; Chikashi Ishioka; Seiichi Takenoshita; Rikiya Abe

doi:10.1007/s12282-009-0157-1

Three cases of kindred with familial breast cancer in which carrier detection by BRCA gene testing was performed on family members

Tadashi Nomizu, Takeshi Sakuma, Mutsuo Yamada, Masami Matsuzaki, Naoto Katagata, Fumiaki Watanabe, Mitsuhiro Nihei, Chikashi Ishioka, Seiichi Takenoshita, Rikiya Abe

Division of Cancer Science

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We performed presymptomatic carrier detection by BRCA gene testing of the family members of three familial breast cancer kindred diagnosed with pathogenetic mutation in BRCA genes. All members were over 20 years of age. We explained familial breast cancer and BRCA gene testing, and obtained autonomic consent before gene testing. Genetic testing revealed twins in a family were dizygotic. In another family bilateral breast cancer occurred in a carrier after five years of genetic testing. Carriers are at high risk of breast cancer and have to receive breast cancer screening and familial tumor counseling. Non-carriers are at the same risk of breast cancer as the general population.

Original language	English
Pages (from-to)	270-274
Number of pages	5
Journal	Breast Cancer
Volume	19
Issue number	3
DOIs	https://doi.org/10.1007/s12282-009-0157-1
Publication status	Published - 2012 Jul 1

Keywords

BRCA gene testing
Carrier detection
Familial breast cancer
Familial tumor counseling
Hereditary breast cancer

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12282-009-0157-1

Cite this

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title = "Three cases of kindred with familial breast cancer in which carrier detection by BRCA gene testing was performed on family members",

abstract = "We performed presymptomatic carrier detection by BRCA gene testing of the family members of three familial breast cancer kindred diagnosed with pathogenetic mutation in BRCA genes. All members were over 20 years of age. We explained familial breast cancer and BRCA gene testing, and obtained autonomic consent before gene testing. Genetic testing revealed twins in a family were dizygotic. In another family bilateral breast cancer occurred in a carrier after five years of genetic testing. Carriers are at high risk of breast cancer and have to receive breast cancer screening and familial tumor counseling. Non-carriers are at the same risk of breast cancer as the general population.",

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doi = "10.1007/s12282-009-0157-1",

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T1 - Three cases of kindred with familial breast cancer in which carrier detection by BRCA gene testing was performed on family members

AU - Nomizu, Tadashi

AU - Sakuma, Takeshi

AU - Yamada, Mutsuo

AU - Matsuzaki, Masami

AU - Katagata, Naoto

AU - Watanabe, Fumiaki

AU - Nihei, Mitsuhiro

AU - Ishioka, Chikashi

AU - Takenoshita, Seiichi

AU - Abe, Rikiya

PY - 2012/7/1

Y1 - 2012/7/1

N2 - We performed presymptomatic carrier detection by BRCA gene testing of the family members of three familial breast cancer kindred diagnosed with pathogenetic mutation in BRCA genes. All members were over 20 years of age. We explained familial breast cancer and BRCA gene testing, and obtained autonomic consent before gene testing. Genetic testing revealed twins in a family were dizygotic. In another family bilateral breast cancer occurred in a carrier after five years of genetic testing. Carriers are at high risk of breast cancer and have to receive breast cancer screening and familial tumor counseling. Non-carriers are at the same risk of breast cancer as the general population.

AB - We performed presymptomatic carrier detection by BRCA gene testing of the family members of three familial breast cancer kindred diagnosed with pathogenetic mutation in BRCA genes. All members were over 20 years of age. We explained familial breast cancer and BRCA gene testing, and obtained autonomic consent before gene testing. Genetic testing revealed twins in a family were dizygotic. In another family bilateral breast cancer occurred in a carrier after five years of genetic testing. Carriers are at high risk of breast cancer and have to receive breast cancer screening and familial tumor counseling. Non-carriers are at the same risk of breast cancer as the general population.

KW - BRCA gene testing

KW - Carrier detection

KW - Familial breast cancer

KW - Familial tumor counseling

KW - Hereditary breast cancer

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Three cases of kindred with familial breast cancer in which carrier detection by BRCA gene testing was performed on family members

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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