Three Cases of Clinical or Preclinical Cushing's Syndrome due to Adrenocorticotropic Hormone-Independent Bilateral Adrenocortical Macronodular Hyperplasia: Pituitary-Adrenocortical Function and Immunohistochemistry

Osamu Murakami, Fumitoshi Satoh, Kazuhiro Takahashi, Kazuhito Totsune, Masahiko Sone, Makoto Ohneda, Keishi Abe, Takashi Suzuki, Hironobu Sasano, Toraichi Mouri

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We performed pituitary-adrenocortical function test and analysis of plasma steroids in three cases of adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia, and examined the plasma cortisol response to meal and oral glucose in two cases. On pathological examination, nodules were mainly composed of clear cells and some nests of compact cells were observed. Immunohistochemistry of steroidogenic enzymes showed positive P-450C17 only in the compact cells and positive 3β-hydroxysteroid dehydrogenase only in the clear cells. These cases were similar to clinical or preclinical Cushing's syndrome due to adenoma in both pituitary-adrenocortical function and plasma steroid patterns, but different from adenoma cases in the distribution of steroidogenic enzymes.

Original languageEnglish
Pages (from-to)1074-1081
Number of pages8
JournalInternal Medicine
Volume34
Issue number11
DOIs
Publication statusPublished - 1995

Keywords

  • 3β-hydroxysteroid dehydrogenase
  • corticotropin-releasing hormone
  • cortisol
  • dexamethasone
  • gastric inhibitory polypeptide
  • steroidogenic cytochromes P-450

ASJC Scopus subject areas

  • Internal Medicine

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