Three-axis model for atg recruitment in autophagy against Salmonella

Takeshi Noda, Shun Kageyama, Naonobu Fujita, Tamotsu Yoshimori

    Research output: Contribution to journalReview articlepeer-review

    14 Citations (Scopus)

    Abstract

    Salmonella enterica serovar Typhimurium enter epithelial cells and take up residence there. Within epithelial cells, a portion of the bacteria are surrounded by an autophagosome-like double-membrane structure, and they are still residing within the Salmonella-containing vacuole (SCV). In this paper, we will discuss how the autophagy machinery is recruited in proximity to Salmonella. The formation of this double membrane requires Atg9L1 and FIP200; these proteins are important for autophagy-specific recruitment of the PI3-kinase complex. In the absence of Atg9L1, FIP200, and PI3-kinase activity, LC3 is still recruited to the vicinity of Salmonella. We propose a novel model in which the mechanism of LC3 recruitment is separate from the generation of the isolation membrane. There exist at least three axes in Atg recruitment: ULK1 complex, Atg9L1, and Atg16L complex.

    Original languageEnglish
    Article number389562
    JournalInternational Journal of Cell Biology
    DOIs
    Publication statusPublished - 2012

    ASJC Scopus subject areas

    • Cell Biology

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