Thermodynamics of complexation between thiourea-based receptor and acetate in water/acetonitrile mixture

Takaya Suzuki, Yuuta Shibuya, Takaya Sato, Seiichi Nishizawa, Itaru Sato, Akira Yamaguchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


A thiourea-based receptor has been extensively studied for selective anion recognition for reasons of its strong hydrogen bond donor ability. In the present study, the thermodynamics of complexation between a thiourea-based receptor and acetate was examined in a water/acetonitrile mixture. The receptor used in this study was N,N'-bis(p-nitrophenyl)thiourea (BNPTU). UV/vis spectroscopic titration and isothermal titration calorimetry (ITC) experiments clearly revealed endothermic and entropy-driven complexation of BNPTU with acetate in water/acetonitrile mixtures. Since the endothermic peaks found in water/acetonitrile mixtures were about three times greater than those in acetonitrile, it appears that preferential hydration of both receptor and acetate was responsible for the endothermic and entropy-driven complexation reaction. The thermodynamic properties found in this study have the potential to contribute to the design of a thiourea-based anion receptor.

Original languageEnglish
Pages (from-to)741-744
Number of pages4
Journalanalytical sciences
Issue number7
Publication statusPublished - 2016


  • Anion recognition
  • Hydrogen bonding
  • Thiourea

ASJC Scopus subject areas

  • Analytical Chemistry


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