Therapy-resistant, spontaneously remitting generalized neutrophilic eccrine hidradenitis in a healthy patient decreases the expression of dermcidin in affected eccrine glands

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Abstract

We describe a healthy 69-year-old Japanese man with generalized neutrophilic eccrine hidradenitis (NEH). He visited our outpatient clinic with a 15-year history of disseminated pruritic papules on his trunk and extremities; the eruptions, however, were limited to the summer months. Histological findings reveal a dense accumulation of neutrophils around the sweat glands with degenerated secretary coils. Interestingly, immunohistochemical staining showed that the expression of dermcidin on the secretory portion of eccrine glands was significantly decreased in the affected lesion. To our knowledge, this is the first report in English of generalized NEH in a healthy adult that shows the downregulation of the expression of dermcidin in affected eccrine glands.

Original languageEnglish
Pages (from-to)228-234
Number of pages7
JournalCase Reports in Dermatology
Volume3
Issue number3
DOIs
Publication statusPublished - 2011 Sep

Keywords

  • Dermcidin
  • Eccrine glands
  • Neutrophilic eccrine hidradenitis

ASJC Scopus subject areas

  • Dermatology

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