[Therapeutic strategy for neuroendocrine tumor of the rectum].

Shinobu Ohnuma, Takeshi Naitoh, Sho Haneda, Katsuyoshi Kudoh, Atushi Kohyama, Munenori Nagao, Naoki Tanaka, Hiroyuki Sasaki, Takeshi Aoki, Tomoya Abe, Hiroaki Musha, Takanori Morikawa, Hiroshi Yoshida, Fuyuhiko Motoi, Y. Katayose, Chikashi Shibata, Michiaki Unno

Research output: Contribution to journalArticle

Abstract

The clinicopathological features of neuroendocrine tumor (NET) of the rectum were retrospectively analyzed in 25 patients( 17 men and 8 women; mean age, 57 years[ 30-78 years]) at Tohoku University Hospital from January 1998 to December 2012. The average diameter of 25 tumors was 15 mm (5-70 mm). Local resections and rectal resections with lymph node dissection were performed in 16 and 9 tumors, respectively. Three of the 9 tumors had lymph node metastases (33%), including 2 tumors with a diameter of 10 mm. In a median follow-up of 48 months, tumor recurrence was observed in 3 of 25 patients( 12%); local recurrence was observed in 1 patient; and liver metastasis was observed in 2 patients. Of the 2 patients with liver metastasis, liver metastasis recurred in a patient whose primary tumor, with a diameter of 10 mm, had been locally resected 40 months ago. According to histopathological analysis, 3 primary tumors with local recurrence or liver metastasis were categorized as G2 or G3 according to the World Health Organization (WHO) classification. Tumors with a diameter of ≥10 mm, in principle, may be removed by rectal resection with lymph node dissection. However, histopathological findings such as a proliferation of tumor cells should also be taken into consideration when deciding the treatment strategy for rectal NET.

Original languageEnglish
Pages (from-to)2077-2079
Number of pages3
JournalUnknown Journal
Volume40
Issue number12
Publication statusPublished - 2013 Nov

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Ohnuma, S., Naitoh, T., Haneda, S., Kudoh, K., Kohyama, A., Nagao, M., Tanaka, N., Sasaki, H., Aoki, T., Abe, T., Musha, H., Morikawa, T., Yoshida, H., Motoi, F., Katayose, Y., Shibata, C., & Unno, M. (2013). [Therapeutic strategy for neuroendocrine tumor of the rectum]. Unknown Journal, 40(12), 2077-2079.