Therapeutic mechanism of repetitive transcranial magnetic stimulation (rTMS)—a monkey PET study

Takuya Hayashi, Noboru Teramoto, Hiroshi Watabe, Yohichiro Ohta, Hiroshi Jino, Hidehiro Iida, Takashi Ohnishi, Etsuko Imabayashi, Hiroshi Matsuda, Shingo Okabe, Yoshikazu Ugawa, Yukio Nonaka, Norimasa Ejima, Tohru Sawada

Research output: Contribution to journalArticlepeer-review


Repetitive transcranial magnetic stimulation (rTMS) has recently been assessed as a non-invasive treatment modality for neuropsychiatric disorders. However, the mechanisms underlying the therapeutic effects are still not understood. Studies in rodents revealed lasting effects in limbic-related regions, but species difference in brain structures makes it difficult to infer the regional effect in primate brain. To reveal how rTMS affects primate brain function, we performed positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) and 11C-raclopride (RAC) in anaesthetized macaque monkeys. A total of 2000 pulses of 5Hz-rTMS were delivered on the unilateral primary motor cortex using a small coil. Voxel-based analysis revealed statistically robust changes in FDG activity in the motor, cingulate, and orbitofrontal cortices, as well as in binding potential of RAC in the ventral striatum. Interestingly, the change in FDG activity persisted at least 8 days. These results demonstrate that motor cortical rTMS induces dynamic functional changes in motor and limbic associated structures, suggesting its therapeutic effect on dysfunction of motor and motivation system.

Original languageEnglish
Pages (from-to)186-190
Number of pages5
JournalInternational Congress Series
Issue numberC
Publication statusPublished - 2004
Externally publishedYes


  • Limbic
  • Magnetic
  • Motor
  • PET
  • Transcranial

ASJC Scopus subject areas

  • Medicine(all)


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