Therapeutic efficacy of latoconazole in formulations of clinical use on experimental dermatophytosis in guinea pigs

H. Oka, Y. Niwano, T. Ohmi, T. Tanake, M. Uchida, H. Yamaguchi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Therapeutic efficacy of clinical dosage forms of latoconazole (NND-318, CAS101530-10-3), a related compound of ketene dithioacetals with an imidazole ring, was examined on two experimental tinea models: a recently developed tinea pedis model and a conventional tinea corporis model in guinea pigs. The efficacy of the dosage forms was estimated on the basis of the rate of fungus-positive skin cultures and/or the score of skin lesions, and was compared to the other antifungal agents, bifonazole, clotrimazole and tolnaftate. While these reference agents exhibited curative effect on the tinea corporis model, the tinea pedis model was considerably resistant to the therapeutic treatment of the agents. The cream preparation and solution of latoconazole at concentrations of more than 0.25% were highly effective in either tinea models, and at concentrations of more than 1%, latoconazole achieved complete mycological cure. These results suggest that 1% of latoconazole is an optimal concentration for clinical use.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalArzneimittel-Forschung/Drug Research
Volume42
Issue number3
Publication statusPublished - 1992 Jan 1

Keywords

  • CAS 101530-10-3
  • NND-318
  • antifungal agents
  • dermatomycoses, experimental
  • latoconazole, pharmacology

ASJC Scopus subject areas

  • Drug Discovery

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