Therapeutic effect of cisplatin given with a lymphatic drug delivery system on false-negative metastatic lymph nodes

Asuka Tada, Sachiko Horie, Shiro Mori, Tetsuya Kodama

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Systemic administration of drugs into the blood circulation is standard treatment for prevention of metastasis. However, systemic delivery cannot maintain sufficiently high concentrations of anticancer drugs in lymph nodes (LN). Here, we show that giving cisplatin (CDDP) using a lymphatic drug delivery system (LDDS) has the potential to treat false-negative metastatic LN. We found that in MXH10/Mo-lpr/lpr mice, which develop systemic swelling of LN up to 10 mm in diameter, accumulation of indocyanine green (ICG), which has a similar molecular weight to CDDP, in a target LN was greater for lymphatic delivery of ICG than for systemic (i.v.) administration. Furthermore, CDDP administration with a LDDS inhibited tumor growth in false-negative metastatic LN and produced fewer adverse effects than systemically given CDDP. We anticipate that drug delivery using a LDDS will, in time, replace systemic chemotherapy for the treatment of false-negative metastatic LN.

Original languageEnglish
Pages (from-to)2115-2121
Number of pages7
JournalCancer science
Volume108
Issue number11
DOIs
Publication statusPublished - 2017 Nov

Keywords

  • Cisplatin
  • MXH10/Mo-lpr/lpr mouse
  • lymph node metastasis
  • lymphatic drug delivery system
  • lymphatic network

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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