Therapeutic advantage of angiotensin converting enzyme inhibitors in chronic glomerulonephritis

Ken Omata, Takao Saito, Hiroshi Sato, Tatsuyuki Sato, Fumiaki Abe, Masaaki Yamada, Hiraku Yaoita, Yoshimi Endo, Sadayoshi Ito, Msayuki Kanazawa, Keishi Abe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hypertension in chronic progressive renal disease is a major clinical problem leading to renal function loss. We studied the influence of ambulatory blood pressure (ABP) and the effect of hypertension therapy on renal function in 116 patients with chronic glomerulonephritis. Patients were subdivided as hypertensive, normotensive and hypotensive according to the level of ABP and age. Hypotensive subjects showed improvement of renal function and normotensive subjects showed slower rate of progression of renal function loss than hypertensives, suggesting the adequate level of ABP was 100-125/55-75 mm Hg in patients less than 40 years old, 100-135/60-80 mm Hg in patients 40-60 years old, and 105-140/60-85 mm Hg in patients over 60 years, respectively. The renal protection of calcium antagonists was associated with achieving lower blood pressure levels, whereas the blood pressure level did not affect progression of renal function in patient treated with angiotensin converting enzyme (ACE) inhibitor. ACE inhibitor, but not calcium antagonists, showed a reduction of urinary protein excretion. Thus, the mechanisms of renal protection were different between ACE inhibitors and calcium antagonists. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalImmunopharmacology
Volume44
Issue number1-2
DOIs
Publication statusPublished - 1999 Oct 15
Externally publishedYes

Keywords

  • Angiotensin converting enzyme (ACE) inhibitor
  • Calcium antagonist
  • Chronic renal disease

ASJC Scopus subject areas

  • Pharmacology

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