The vasohibin family: Novel regulators of angiogenesis

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)

Abstract

Angiogenesis is thought to be regulated by the local balance between angiogenesis stimulators and angiogenesis inhibitors. A number of endogenous regulators of angiogenesis have been found in the body. We recently isolated vasohibin-1 (VASH1) as a negative feedback regulator of angiogenesis produced by endothelial cells, and VASH2 as a homologue of VASH1 thereafter. We found that VASH1 was expressed in endothelial cells to terminate angiogenesis, whereas VASH2 promoted angiogenesis, in the mouse model of angiogenesis. This mini-review will focus on the vasohibin family in relation to the regulation of angiogenesis.

Original languageEnglish
Pages (from-to)262-266
Number of pages5
JournalVascular Pharmacology
Volume56
Issue number5-6
DOIs
Publication statusPublished - 2012 May

Keywords

  • Angiogenesis
  • Vasohibin

ASJC Scopus subject areas

  • Physiology
  • Molecular Medicine
  • Pharmacology

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