The vasohibin family: Novel regulators of angiogenesis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A number of endogenous regulators of angiogenesis have been found in the body. We isolated vasohibin-1 (VASH1) as a negative feedback regulator of angiogenesis produced by endothelial cells, and then VASH2 as a homologue of VASH1. We further explored that VASH1 is expressed in endothelial cells to terminate angiogenesis, whereas VASH2 is expressed in non-endothelial cells in the sprouting front to promote angiogenesis. This chapter will focus on this vasohibin family members, novel regulators of angiogenesis.

Original languageEnglish
Title of host publicationAngiogenesis and Vascularisation
Subtitle of host publicationCellular and Molecular Mechanisms in Health and Diseases
PublisherSpringer-Verlag Wien
Pages261-267
Number of pages7
ISBN (Electronic)9783709114285
ISBN (Print)3709114276, 9783709114278
DOIs
Publication statusPublished - 2013 Dec 1

Keywords

  • Angiogenesis inhibitors
  • Cancer
  • Tumor angiogenesis
  • VEGF
  • Vasohibin-1
  • Vasohibin-2

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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