The vasohibin family: A novel family for angiogenesis regulation

Research output: Contribution to journalReview articlepeer-review

67 Citations (Scopus)

Abstract

Angiogenesis, a formation of neovessels, is regulated by the local balance between angiogenesis stimulators and inhibitors. A number of such endogenous regulators of angiogenesis have been found in the body. Recently, vasohibin-1 (VASH1) was isolated as a negative feedback regulator of angiogenesis produced by endothelial cells (ECs) and subsequently vasohibin-2 (VASH2) as a homologue of VASH1. It was then explored that VASH1 is expressed in ECs to terminate angiogenesis, whereas VASH2 is expressed in cells other than ECs to promote angiogenesis in the mouse model of angiogenesis. This review will focus on the vasohibin family members, which are novel regulators of angiogenesis.

Original languageEnglish
Pages (from-to)5-11
Number of pages7
JournalJournal of biochemistry
Volume153
Issue number1
DOIs
Publication statusPublished - 2013 Jan

Keywords

  • SVBP
  • angiogenesis
  • endothelial cell
  • vasohibin-1
  • vasohibin-2

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Fingerprint Dive into the research topics of 'The vasohibin family: A novel family for angiogenesis regulation'. Together they form a unique fingerprint.

Cite this