The vasohibin family: A negative regulatory system of angiogenesis genetically programmed in endothelial cells

Yasufumi Sato, Hikaru Sonoda

Research output: Contribution to journalShort surveypeer-review

50 Citations (Scopus)

Abstract

Biological phenomena are under the precise control by the genome. For the regulation of angiogenesis, proangiogenic genes such as VEGFs and angiopoietins are highly conserved, act specifically on endothelial cells, and play a fundamental role. In this sense, nature should prepare specific antiangiogenic genes as well. However, this counterpart of genomic regulation of angiogenesis remains to be established. We recently isolated a novel endothelium-derived angiogenesis inhibitor and named it vasohibin. Vasohibin is dominantly expressed in endothelial cells, induced by the stimulation with VEGF or FGF-2, and selectively affects on endothelial cells and inhibits angiogenesis. Although the mechanism of how vasohibin inhibits angiogenesis remains to be elucidated, our discovery of vasohibin as an endothelium-derived VEGF-inducible angiogenesis inhibitor should shed light on the genomic basis of the negative regulation of angiogenesis.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalArteriosclerosis, thrombosis, and vascular biology
Volume27
Issue number1
DOIs
Publication statusPublished - 2007 Jan

Keywords

  • Angiogenesis inhibitor
  • Endothelial cell
  • Negative feedback
  • VEGF

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'The vasohibin family: A negative regulatory system of angiogenesis genetically programmed in endothelial cells'. Together they form a unique fingerprint.

Cite this