The Upf factor complex interacts with aberrant products derived from mrnas containing a premature termination codon and facilitates their proteasomal degradation

Kazushige Kuroha, Koji Ando, Reiko Nakagawa, Toshifumi Inada

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Background:Up-frameshift (Upf) factors eliminate aberrant mRNAs that contain a premature termination codon (PTC). Results:The Upf complex was recruited to a PTC product and promoted the degradation of a model unfolded protein. Conclusion:Upf factors facilitate the ubiquitin-dependent degradation of products derived from mRNA containing specific PTCs. Significance:The findings reveal a mechanism of quality control that prevents the production of aberrant products derived from mRNAs containing specific PTCs.

Original languageEnglish
Pages (from-to)28630-28640
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
Publication statusPublished - 2013 Oct 4

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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