The UMD TP53 database and website: Update and revisions

Dalil Hamroun, Shunsuke Kato, Chikashi Ishioka, Mireille Claustres, Christophe Béroud, Thierry Soussi

Research output: Contribution to journalReview articlepeer-review

105 Citations (Scopus)

Abstract

Mutation of the p53 gene is the most frequent genetic alteration found in human cancer, but it is also the most frequently reported with more than 22,000 mutations published in 2,000 papers. In 1991, we developed a database and software to handle and analyze all this information. The database has been widely used for clinical analysis and molecular epidemiology. We have expanded the scope of the database by integrating structural, phylogenetic and biological information on wild-type (wt) and mutant TP53. Integration of the TP53 mutant activity database provides unique information that will be useful to both clinicians and scientists. All of this information is available from a new website (www.umd.be:2072/) that will generate a detailed informative page for every TP53 mutant in the database. New tools to check TP53 mutations and minimize errors found in the literature are also available.

Original languageEnglish
Pages (from-to)14-20
Number of pages7
JournalHuman mutation
Volume27
Issue number1
DOIs
Publication statusPublished - 2006 Jan

Keywords

  • Apoptosis
  • Database
  • Mutant activity
  • Mutation
  • TP53
  • Tumor suppressor gene
  • UMD
  • p53

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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