The Ubi brothers reunited

Takeshi Noda, Naonobu Fujita, Tamotsu Yoshimori

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)


    Atg12 and Atg8/LC3 are two ubiquitin-like proteins involved in autophagosome formation. They show several similar characteristics just like brothers evolved from the same ancestor, however, their functional relationship has been obscure. We recently reported that a super protein complex, the Atg16L complex, which consists of multiple Atg12-Atg5 conjugates and the associating protein Atg16L, has an E3-like role in the LC3 lipidation reaction.1 The activated intermediate, LC3-Atg3 (E2) is recruited to the site where the lipidation takes place by virtue of the Atg16L complex. Thus, these two closely resembling systems are connected also in terms of their functions. This finding will provide further important clues as to the origin of the autophagosome membrane, and how the process is regulated by starvation and PtdIns3P signals.

    Original languageEnglish
    Pages (from-to)540-541
    Number of pages2
    Issue number4
    Publication statusPublished - 2008 May 16


    • Atg12
    • Atg16L
    • Atg8
    • Autophagy
    • E3
    • LC3

    ASJC Scopus subject areas

    • Molecular Biology
    • Cell Biology


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