The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: The emerging role in the pathogenesis of Alzheimer's disease

Kazuma Murakami, Yuichi Masuda, Takuji Shirasawa, Takahiko Shimizu, Kazuhiro Irie

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)

Abstract

One hallmark of Alzheimer's disease (AD) is the accumulation of amyloid β (Aβ) peptides in the brain; Aβ mainly consists of 42-mer and 40-mer peptides (Aβ42 and Aβ40). Aβ42 plays a more critical role in the pathogenesis of AD because Aβ42 aggregates much faster and is more toxic than Aβ40. Therefore, there is an urgent need to elucidate the mechanism of aggregation and neurotoxicity of Aβ42 to develop therapeutic agents. Here, we introduce the pathological role of Aβ42 in AD and review our recent findings of the structural analysis of Aβ42 using systematic proline replacement, electron spin resonance and solid-state nuclear magnetic resonance, and the new mechanism of neurotoxicity of Aβ42 through the formation of radicals.

Original languageEnglish
Pages (from-to)S169-S179
JournalGeriatrics and Gerontology International
Volume10
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2010 Jul

Keywords

  • Alzheimer's disease
  • Amyloid
  • Electron spin resonance
  • Nuclear magnetic resonance
  • Oxidative stress

ASJC Scopus subject areas

  • Health(social science)
  • Gerontology
  • Geriatrics and Gerontology

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