TY - JOUR
T1 - The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide
T2 - The emerging role in the pathogenesis of Alzheimer's disease
AU - Murakami, Kazuma
AU - Masuda, Yuichi
AU - Shirasawa, Takuji
AU - Shimizu, Takahiko
AU - Irie, Kazuhiro
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/7
Y1 - 2010/7
N2 - One hallmark of Alzheimer's disease (AD) is the accumulation of amyloid β (Aβ) peptides in the brain; Aβ mainly consists of 42-mer and 40-mer peptides (Aβ42 and Aβ40). Aβ42 plays a more critical role in the pathogenesis of AD because Aβ42 aggregates much faster and is more toxic than Aβ40. Therefore, there is an urgent need to elucidate the mechanism of aggregation and neurotoxicity of Aβ42 to develop therapeutic agents. Here, we introduce the pathological role of Aβ42 in AD and review our recent findings of the structural analysis of Aβ42 using systematic proline replacement, electron spin resonance and solid-state nuclear magnetic resonance, and the new mechanism of neurotoxicity of Aβ42 through the formation of radicals.
AB - One hallmark of Alzheimer's disease (AD) is the accumulation of amyloid β (Aβ) peptides in the brain; Aβ mainly consists of 42-mer and 40-mer peptides (Aβ42 and Aβ40). Aβ42 plays a more critical role in the pathogenesis of AD because Aβ42 aggregates much faster and is more toxic than Aβ40. Therefore, there is an urgent need to elucidate the mechanism of aggregation and neurotoxicity of Aβ42 to develop therapeutic agents. Here, we introduce the pathological role of Aβ42 in AD and review our recent findings of the structural analysis of Aβ42 using systematic proline replacement, electron spin resonance and solid-state nuclear magnetic resonance, and the new mechanism of neurotoxicity of Aβ42 through the formation of radicals.
KW - Alzheimer's disease
KW - Amyloid
KW - Electron spin resonance
KW - Nuclear magnetic resonance
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=77954688012&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954688012&partnerID=8YFLogxK
U2 - 10.1111/j.1447-0594.2010.00598.x
DO - 10.1111/j.1447-0594.2010.00598.x
M3 - Review article
C2 - 20590832
AN - SCOPUS:77954688012
VL - 10
SP - S169-S179
JO - Geriatrics and Gerontology International
JF - Geriatrics and Gerontology International
SN - 1447-0594
IS - SUPPL. 1
ER -