The transcriptional activities of p53 and its homologue p51/p63: Similarities and differences

Akira Shimada, Shunsuke Kato, Kentaro Enjo, Motonobu Osada, Yoji Ikawa, Kenji Kohno, Masuo Obinata, Ryunosuke Kanamaru, Shuntaro Ikawa, Chikashi Ishioka

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

p51/p63 is a novel p53 homologue that has been shown to act as a transcriptional activator through the p53-binding sequence of the p21/WAF1 promoter and to induce apoptosis when it is expressed transiently in a human tumor cell line. We developed transcription assay systems for these two related genes in both Saccharomyces cerevisiae and mammalian cells and used them to investigate the functional similarities and differences of these genes. We found that p51/p63 trans-activated the previously identified p53 target genes, but the degree of the transactivation by p51/p63 differed from that by p53. These results suggest that the cellular signal on p51/p63 cross- talks partially but not completely with that of the p53 pathway.

Original languageEnglish
Pages (from-to)2781-2786
Number of pages6
JournalCancer Research
Volume59
Issue number12
Publication statusPublished - 1999 Jun 15

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The transcriptional activities of p53 and its homologue p51/p63: Similarities and differences'. Together they form a unique fingerprint.

  • Cite this

    Shimada, A., Kato, S., Enjo, K., Osada, M., Ikawa, Y., Kohno, K., Obinata, M., Kanamaru, R., Ikawa, S., & Ishioka, C. (1999). The transcriptional activities of p53 and its homologue p51/p63: Similarities and differences. Cancer Research, 59(12), 2781-2786.