The synthesis of the CD ring of paclitaxel

Kazuoki Nakai, Shigeru Miyamoto, Daisuke Sasuga, Takayuki Doi, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

We have developed a practical synthetic route to the CD ring of paclitaxel. Unsaturated ester 8 was stereo- and regioselectively isomerized to 9. Stereoselective introduction of hydroxy groups and oxetane formation provided potential intermediate 4, which was coupled to an A ring moiety.

Original languageEnglish
Pages (from-to)7859-7862
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number44
DOIs
Publication statusPublished - 2001 Oct 29
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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